The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice

The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice

Six-transmembrane protein of prostate (Stamp2) protects from diabetes and atherosclerosis in mice by way of anti-inflammatory mechanisms. As power irritation is a trademark of pulmonary arterial hypertension (PAH), we investigated the position of Stamp2. Stamp2 expression was considerably lowered within the lung of people with idiopathic PAH, in addition to in experimental PAH. In Stamp2-deficient mice, hypoxia modestly aggravated pulmonary vascular transforming and proper ventricular stress in comparison with WT. As endothelial cell (EC) and pulmonary arterial clean muscle cell (PASMC) phenotypes drive transforming in PAH, we explored the position of Stamp2. Knock-down of Stamp2 in human EC neither affected apoptosis, viability, nor launch of IL-6. Furthermore, Stamp2 deficiency in main PASMC didn’t alter mitogenic or migratory properties.

As Stamp2 deficiency augmented expression of inflammatory cytokines and numbers of CD68-positive cells within the lung, actions of Stamp2 in macrophages might drive vascular transforming. Thus, PASMC responses have been assessed following remedy with conditioned media of main Stamp2-/- or WT macrophages. Stamp2-/- supernatants induced PASMC proliferation and migration stronger in comparison with WT. A cytokine array revealed CXCL12, MCP-1 and IL-6 as most related candidates. Experiments with neutralizing antibodies confirmed the position of those cytokines in driving Stamp2’s responses. In conclusion, Stamp2 deficiency aggravates pulmonary vascular transforming by way of cross-talk between macrophages and PASMC.

Regardless of a considerable pro-inflammatory response, the hemodynamic impact of Stamp2 deficiency is modest suggesting that extra mechanisms aside from irritation are essential to induce extreme PAH. An in vitro comparative examine was achieved to find out the AQP3 expression on 20 surgical biopsy specimens every of OED and OSCC utilizing immunohistochemistry. Twenty specimens of regular oral mucosa have been saved as controls. The outcomes have been statistically analyzed utilizing one-way evaluation of variance and put up hoc evaluation.

 

PolarProtDb: a database of transmembrane and secreted proteins exhibiting apical-basal polarity

Most cells in multicellular organisms are by some means uneven, polarized: sustaining separate membrane domains. Typical examples are the epithelial cells (apical-basal polarization), neurons (dendritic-axonal domains), or migratory cells (with a number one and a trailing edge). Right here we current essentially the most complete database containing experimentally verified mammalian proteins that show polarized sorting or secretion, focusing at epithelial polarity.
Along with the supply cells or tissues, homology-based inferences and transmembrane topology (if relevant) are all offered. PolarProtDb additionally affords an in depth interface displaying all data that could be related for trafficking: together with post-translational modifications (glycosylations and phosphorylations), identified or predicted quick linear motifs conserved throughout orthologs, in addition to potential interplay companions. Information on polarized sorting has to date been scattered throughout myriads of publications, therefore tough to entry.
This data might help researchers in a number of areas, comparable to scanning for potential entry factors of viral brokers like COVID-19. PolarProtDb shall be a helpful useful resource to design future experiments in addition to for comparative analyses.
 The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice
The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice

Transmembrane protein 88 inhibits remodeling progress factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells by way of modulating TGF-β1/Smad pathway

Pleural fibrosis is an irreversible pathological course of occurred within the growth of a number of lung illnesses. TMEM88 is a member of transmembrane (TMEM) household and has been discovered to be concerned within the regulation of fibrogenesis. Nonetheless, the position of TMEM88 in pleural fibrosis stays unknown. On this examine, we aimed to discover the position of TMEM88 in pleural fibrosis in vitro utilizing remodeling progress factor-β1 (TGF-β1)-induced human pleural mesothelial cell line MeT-5A cells. Our outcomes confirmed that the expression ranges of TMEM88 have been downregulated in pleural fibrosis tissues and TGF-β1-treated Met-5A cells.
Overexpression of TMEM88 inhibited the proliferation of Met-5A cells underneath TGF-β1 stimulation. As well as, TMEM88 overexpression prevented TGF-β1-induced extracellular matrix (ECM) accumulation and epithelial-mesenchymal transition (EMT) in Met-5A cells with decreased expression ranges of Col I and fibronectin, elevated ranges of cytokeratin-Eight and E-cadherin, in addition to decreased ranges of vimentin and α-SMA. Moreover, overexpression of TMEM88 inhibited the expression of TGF-β receptor I (TβRI) and TβRII and suppressed the phosphorylation of Smad2 and Smad3 in Met-5A cells. In conclusion, these outcomes indicated that TMEM88 exhibited an anti-fibrotic exercise in pleural fibrosis by way of inhibiting the activation of TGF-β1/Smad signaling pathway. A vital protein of the SARS-CoV-2 virus, the envelope protein E, varieties a homopentameric cation channel that’s vital for virus pathogenicity. Right here we report a 2.1-Å construction and the drug-binding website of E’s transmembrane area (ETM), decided utilizing solid-state NMR spectroscopy. In lipid bilayers that mimic the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane, ETM varieties a five-helix bundle surrounding a slim pore.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein

20-abx263452
  • EUR 230.00
  • EUR 1609.00
  • EUR 328.00
  • 1 µg
  • 50 ug
  • 5 ug
  • Shipped within 5-10 working days.

Recombinant Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)

4-RPH166Ra01
  • EUR 508.58
  • EUR 239.00
  • EUR 1632.16
  • EUR 610.72
  • EUR 1121.44
  • EUR 403.00
  • EUR 3930.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q5M869
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 22.8kDa
  • Isoelectric Point: 6.4
Description: Recombinant Rat Signaling Threshold Regulating Transmembrane Adaptor 1 expressed in: E.coli

Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein

20-abx069095
  • EUR 704.00
  • EUR 286.00
  • EUR 2193.00
  • EUR 843.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat)

4-PAH166Ra01
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)

SIT1 Signaling Threshold Regulating Transmembrane Adaptor 1 Human Recombinant Protein

PROTQ9Y3P8 Regular: 5ug
EUR 317
Description: _x000D_ SIT1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (62-196 a.a.) and having a molecular mass of 16.9kDa (Molecular weight on SDS-PAGE will appear higher).;SIT1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), APC

4-PAH166Ra01-APC
  • EUR 364.00
  • EUR 3545.00
  • EUR 980.00
  • EUR 467.00
  • EUR 227.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with APC.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), Biotinylated

4-PAH166Ra01-Biotin
  • EUR 325.00
  • EUR 2658.00
  • EUR 777.00
  • EUR 400.00
  • EUR 225.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with Biotin.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), Cy3

4-PAH166Ra01-Cy3
  • EUR 444.00
  • EUR 4685.00
  • EUR 1265.00
  • EUR 581.00
  • EUR 261.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with Cy3.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), FITC

4-PAH166Ra01-FITC
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with FITC.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), HRP

4-PAH166Ra01-HRP
  • EUR 332.00
  • EUR 3089.00
  • EUR 866.00
  • EUR 421.00
  • EUR 213.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with HRP.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), PE

4-PAH166Ra01-PE
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with PE.

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Polyclonal Antibody (Rat), APC-Cy7

4-PAH166Ra01-APC-Cy7
  • EUR 608.00
  • EUR 6970.00
  • EUR 1840.00
  • EUR 814.00
  • EUR 335.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: SIT1 (Ser2~Pro175)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1). This antibody is labeled with APC-Cy7.

Lck Interacting Transmembrane Adaptor 1 Protein

20-abx261198
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

T Cell Receptor Associated Transmembrane Adaptor 1 Antibody

20-abx115973
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

GRB2 Binding Adaptor Protein, Transmembrane (GAPT) Antibody

abx031219-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

GRB2 Binding Adaptor Protein, Transmembrane (GAPT) Antibody

abx031219-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Hh Signaling Pathway Antagonist

1659-1
EUR 180

DiscoveryProbe? Neuronal Signaling Library

L1026-.1 100 uL/well(10 mM solution)
EUR 4968

Anti-ARH / LDL receptor adaptor antibody

STJ70389 100 µg
EUR 359

Adhesion Regulating Molecule 1

PR27196 2 ug
EUR 191

Nck Adaptor Protein 1 Antibody

20-abx114029
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

NCK Adaptor Protein 1 Antibody

20-abx137473
  • EUR 704.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Transcriptional Adaptor 1 (TADA1L) Antibody

abx238473-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

DiscoveryProbe? NF-?B Signaling Library

L1044-.1 100 uL/well(10 mM solution)
EUR 1442

Transcriptional Regulating Factor 1 (TRERF1) Antibody

20-abx212804
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Adhesion Regulating Molecule 1 (ADRM1) Antibody

20-abx110859
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Transcriptional Regulating Factor 1 (TRERF1) Antibody

20-abx116171
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Transcriptional-Regulating Factor 1 (TRERF1) Antibody

20-abx119416
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Adhesion Regulating Molecule 1 (ADRM1) Antibody

20-abx128969
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Transcriptional Regulating Factor 1 (TRERF1) Antibody

20-abx130703
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Transcriptional Regulating Factor 1 (TRERF1) Antibody

20-abx130704
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Transcriptional-Regulating Factor 1 (TRERF1) Antibody

abx238962-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Transcriptional Regulating Factor 1 (TRERF1) Antibody

20-abx325287
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Human GRB2 Binding Adaptor Protein, Transmembrane (GAPT) ELISA Kit

abx384973-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Mouse GRB2 Binding Adaptor Protein, Transmembrane (GAPT) ELISA Kit

abx389460-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Anti-Periphilin 1 Antibody

A06996-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody

A07491-1 100ul
EUR 397
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody

A07972-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody

A09176-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody

A09467-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Anti-NPDC-1 Antibody

A12846-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody

A05494-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody

A00901-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody

A01502-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody

A01530-1 100ug
EUR 455
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Bag-1 Antibody

A02423-1 50 ul
EUR 397
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

Anti-TUB 1 Antibody

A02917-1 100ug/vial
EUR 294

Anti-Dok-1 Antibody

A03039-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-TFIIIB90-1 Antibody

A03761-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody

A03828-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody

A00138-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-PAI-1 Antibody

A00637-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-Transmembrane protein 37 antibody

STJ71308 100 µg
EUR 260

Anti-Pyrophosphatase 1/PPA1 Antibody

A07485-1 100ug/vial
EUR 334

Anti-TCP-1 eta Antibody

A08169-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat.

Anti-Relaxin 1/RLN1 Antibody

A08367-1 100ug/vial
EUR 334

Anti-TCP-1 zeta Antibody

A09373-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat.

Anti-CHST8/Galnac4St 1 Antibody

A10989-1 100ul
EUR 397
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Musashi 1/Msi1 Antibody

A05052-1 100ug/vial
EUR 334

Anti-LOX-1/OLR1 Antibody

A00760-1 100ug/vial
EUR 294

Anti-Syndecan-1/SDC1 Antibody

A00991-1 100ug/vial
EUR 294

Anti-IRAK-1/IRAK1 Antibody

A01021-1 100ug/vial
EUR 334

Anti-Neurexin 1/NRXN1 Antibody

A01490-1 100ug/vial
EUR 334

Anti-Hexokinase 1/HK1 Antibody

A01504-1 100ug/vial
EUR 334

Anti-Synaptotagmin 1/SYT1 Antibody

A02314-1 100ug/vial
EUR 334

Anti-Syntenin-1 Monoclonal Antibody

A02475-1 100ul
EUR 397
Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig.

Anti-Dsg1/Desmoglein 1 Antibody

A02655-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti-CAF-1 p150 Antibody

A02732-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse.

Anti-Talin 1/TLN1 Antibody

A02859-1 100ug/vial
EUR 334

Anti-Islet 1/ISL1 Antibody

A02969-1 100ug/vial
EUR 334

Anti-TNF Receptor 1 Antibody

A00294-1 200ug
EUR 522
Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

Anti-Galectin 1/Lgals1 Antibody

A00470-1 100ug/vial
EUR 334

Anti-Angiopoietin 1/ANGPT1 Antibody

PA1333-1 100ug/vial
EUR 334

Anti-Presenilin 1 Monoclonal Antibody

M00138-1 100ug
EUR 397
Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Galectin 1 Monoclonal Antibody

M00470-1 100ug
EUR 397
Description: Rabbit Monoclonal Galectin 1 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-DJ-1 Monoclonal Antibody

M00757-1 100ul
EUR 397
Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human.

Anti-Enolase 1 Monoclonal Antibody

M01250-1 100ul
EUR 397
Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse

Anti-Dynamin 1 Monoclonal Antibody

M02536-1 100ug
EUR 397
Description: Rabbit Monoclonal Dynamin 1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-Esrp-1 Monoclonal Antibody

M06068-1 100uL
EUR 443
Description: Mouse Monoclonal Esrp-1 Antibody. Validated in WB and tested in Human.

Anti-Galectin 1/LGALS1 Antibody

PB9240-1 100ug/vial
EUR 334

SH2B Adaptor Protein 1 (SH2B1) Antibody

20-abx004263
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

20-abx141775
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

abx028518-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

abx028518-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

abx237818-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

20-abx320666
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

SHC Adaptor Protein 1 (SHC1) Antibody

abx331408-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

SHC Adaptor Protein 1 (SHC1) Antibody

abx332006-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

SH2B Adaptor Protein 1 (SH2B1) Antibody

20-abx321761
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

20-abx007485
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

20-abx008997
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

20-abx004794
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

20-abx103800
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

abx117002-100ug 100 ug
EUR 467
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

20-abx131293
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

20-abx171296
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
  • Please enquire.

Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

abx011152-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

abx033757-400ul 400 ul
EUR 551
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

abx033757-80l 80 µl
EUR 321
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

abx033758-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

abx033758-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

20-abx302107
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

abx230640-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

20-abx000666
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Anti-HO-1 Monoclonal Antibody (HO-1-2)

M00253-1 1mg
EUR 397
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

Anti-CELSR3/Flamingo Homolog 1 Antibody

A07204-1 100ul
EUR 397
Description: Rabbit Polyclonal CELSR3/Flamingo Homolog 1 Antibody. Validated in IF and tested in Human, Mouse, Rat.

Anti-LPCAT2/Acyltransferase Like 1 Antibody

A07471-1 100ul
EUR 397
Description: Rabbit Polyclonal LPCAT2/Acyltransferase Like 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Hyaluronan synthase 1/HAS1 Antibody

A04784-1 100ug/vial
EUR 334

Anti-Liver Carboxylesterase 1/CES1 Antibody

A01741-1 100ug/vial
EUR 334

Anti-EBP50/NHERF-1/SLC9A3R1 Antibody

A02427-1 100ug/vial
EUR 334

Anti-IL1R2/Il 1 Rii Antibody

A03106-1 1 ml
EUR 397
Description: Rabbit Polyclonal IL1R2/Il 1 Rii Antibody. Validated in IP, WB and tested in Human.

Anti-HIF-1 alpha/HIF1A Antibody

A00013-1 100ug/vial
EUR 294

Anti-Cleaved-Notch 1 (V1754) Antibody

A00033-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-Notch 1 (V1754) Antibody (NOTCH1) detection.tested for WB in Human, Mouse, Rat.

Anti-HDAC-1 (C-terminus) Antibody

A00256-1 100uL
EUR 443
Description: Rabbit Polyclonal HDAC-1 (C-terminus) Antibody. Validated in IF, IHC, WB and tested in Human.

Anti-VEGF Receptor 1/FLT1 Antibody

A00534-1 100ug/vial
EUR 294

Anti-Integrin alpha 1/ITGA1 Antibody

PA1045-1 100ug/vial
EUR 334

Anti-Caspase-1(P20)/CASP1 Antibody

PA1440-1 100ug/vial
EUR 294

Anti-VEGF Receptor 1/FLT1 Antibody

PA1966-1 100ug/vial
EUR 294

Anti-Sumo 1 Rabbit Monoclonal Antibody

M00631-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Sumo 1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Cytokeratin 1 Rabbit Monoclonal Antibody

M01639-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cytokeratin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Mitofusin 1 Antibody (monoclonal, 3H3)

M02172-1 100ug/vial
EUR 294

Anti-Phospho-Beclin-1 (Ser295) Antibody

P00327-1 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-Beclin-1 (Ser295) Antibody. Validated in WB and tested in Human.

Anti-Phospho-Raf-1 (Ser642) Antibody

P00446-1 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-Raf-1 (Ser642) Antibody. Validated in WB and tested in Human, Rat.

Polyclonal Goat Anti-ARH / LDL receptor adaptor Antibody

AMM04897G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-ARH / LDL receptor adaptor . This antibody is tested and proven to work in the following applications:

Appetite-Regulating Hormone (GHRL) Antibody

abx021162-1mg 1 mg
EUR 1010
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

abx021163-1mg 1 mg
EUR 1010
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

abx021164-1mg 1 mg
EUR 1066
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

20-abx112712
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Myogenesis-Regulating Glycosidase (KIAA1161) Antibody

abx037061-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

20-abx132285
  • EUR 328.00
  • EUR 746.00
  • EUR 425.00
  • EUR 112.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • Please enquire.

Appetite-Regulating Hormone (GHRL) Antibody

20-abx132316
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

TP53-Regulating Kinase (TP53RK) Antibody

abx029219-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

TP53-Regulating Kinase (TP53RK) Antibody

abx029219-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

20-abx320425
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

abx233452-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Appetite-Regulating Hormone (GHRL) Antibody

abx448546-100ug 100 ug
EUR 523
  • Shipped within 5-12 working days.

Myogenesis-Regulating Glycosidase (KIAA1161) Antibody

20-abx301454
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Appetite-Regulating Hormone (GHRL) Antibody

20-abx001192
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.
The protein deviates from the best α-helical geometry as a result of three phenylalanine residues, which stack inside every helix and between helices. Along with valine and leucine interdigitation, these trigger a dehydrated pore in contrast with the viroporins of influenza viruses and HIV. Hexamethylene amiloride binds the polar amino-terminal lumen, whereas acidic pH impacts the carboxy-terminal conformation. Thus, the N- and C-terminal halves of this bipartite channel might work together with different viral and host proteins semi-independently. The construction units the stage for designing E inhibitors as antiviral medication.

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